[Genaxxon Bioscience] [beta]-Amyloid (10-20) - YEVHHQKLVFF

[Genaxxon Bioscience] [beta]-Amyloid (10-20) - YEVHHQKLVFF

 

Order number: P2304.9505

Shipping: shipped at RT, store at -20°C

 

Technical Data:

Specifications:
Sequence: YEVHHQKLVFF
Purity: >95% (HPLC)

application:

Fibrilization, fibrillogenesis studies

Source

synthetic

Sicherheits Hinweise / Safety

Klassifizierungen / Classification

eclass-Nr: 34-16-04-90

 

[beta]-Amyloid (10-20) (peptide sequence: YEVHHQKLVFF) ist used as a test peptide for the hydrophilic part of the complete Amyloid beta 1-42 peptide.

Amyloid-beta (1-42) human is an Alzheimer desease peptide. Characteristic of Alzheimer disease is the accumulation of amyloid plaques in the brain. The major components of these plaques are 39-42 residue-long amyloid-ß-peptides, which form insoluble fibrils via self-assembly. The amyloid-ß-peptides are fragments of the broadly distributed, membrane-bound amyloid precursor protein APP, encoded on chromosome 21. They are formed from the proteolytic cleavage of APP by ß- and g-secretases. Cleavage occurs after residue 40 or after residue 42. Even slightly increased amounts of Amyloid-beta 1-42 are described to be sufficient to cause Alzheimer's disease.