[Definigen] Hepatocyte WT

[Definigen] Hepatocyte WT

 

 

Product ID	Def-HEP WT
Format	Cryopreserved
Cell number	4-6 million cells
Genetic background	Wild-type
Viability	>70%

 

Benefits

• Highly standardized with > 98% functionally mature human hepatocytes
• Reliable, consistent peformance delivers biologically relevant data
• Verified wild-type donor genetics and karyotype
• Stable function in culture over a +20 day window

Normal physiology includes:

• CYP450 induced activities
• Expression of hepatocyte proteins, including A1AT, ALB, HNF4a
• Secretion of physiologically relevant levels of albumin and urea
• Expression of a range of key hepatitis B & C markers
• Uptake of LDL

 

With the ability to reliably generate functionally mature human hepatocytes from iPSCs, DefiniGEN brings all the advantages of iPSC technology to hepatocyte studies - cell models that possess human-relevant physiology and that are available in virtually unlimited amounts with the same genetic background.

DefiniGEN's human hepatocytes remain functionally stable over a prolonged period of time in culture, making them ideal for drug discovery, drug metabolism, and toxicology-related studies. They also express key hepatitis markers such as CD81, SR-B1, Claudin-1 and Occludin at similar levels to primary human hepatocytes, making them an effective model for hepatitis lifecycle studies.