[Calixar] DOT1L

[Calixar]  DOT1L

Target class

Epigenetic

 

Accession number

NP_115871.1

 

 

Target Name

DOT1L

 

Target Alias

KMT4, KIAA1814

 

Origin

Human

 

Theori. MW

47.9 kDa

 

Affinity tag

TEV

 

Expression system

Expressed in E. coli

 

Purity

Refer to CoA for Purity

 

Purification method

Immobilised metal affinity chromatography

 

Sample Buffer

Protein in 25mM Hepes/NaOH pH7.4, 250mM NaCl, 50% Glycerol, 2mM DTT. Frozen solution.

 

Specified activity

Refer to CoA

 

Application

For Research Only

 

Storage conditions

1 year at -70°C.

 

Usage disclaimer

For Research Only

 

 

DOT1L (disruptor of telomeric silencing 1-like) is an epigenetic protein that functions as a histone methyltransferase. It is responsible for adding methyl groups to specific lysine residues on histones, leading to the formation of heterochromatin and repression of gene expression. DOT1L is widely expressed in many tissues and is important for normal development and cellular function. It is involved in various biological processes, including transcriptional regulation, DNA damage response, and cell cycle progression. Aberrant DOT1L activity has been implicated in various diseases, including cancer, leukemia, and neurodevelopmental disorders. DOT1L inhibitors are being developed for therapeutic purposes, and understanding its function is important for developing new therapies.