[Calixar] Adenosine receptor A2A - Class A GPCR

[Calixar]  Adenosine receptor A2A - Class A GPCR

• Target name: Adenosine receptor A2A (A2AR)
• Gene: ADORA2A
• Uniprot Accession: P29274
• Origin: Human (Homo sapiens)
• Class: Class A GPCR
• Sequence: Full-length, wild type sequence, with a N-terminus Strep tag II, 8xHis-tag, and TEV protease cleavage site.
• Affinity Tag: His/Strep (both N-terminal)
• Catalogue number: PP1
• Theor. MW: 47,7kDa
• Shipment temperature: Dry Ice
• Storage conditions: Store at -80°C

• Expression system: Sf9 insect cells (baculovirus)
• Purity: >90%
• Purification: Immobilized Metal Affinity Chromatography
• Activity: Confirmed by radiobinding assay
• Concentration: Up to 5mg/ml
• Sample buffer: PBS, 0.05%/0.006% DDM/CHS OR
  50mM Hepes pH 7.4, 200mM NaCl, 0.05%/0.006% DDM/CHS
• Available quantity: From 10µg up to mg scale

 

CALIXAR’s Adenosine receptor A2A aids in the discovery, development, and validation of new molecules as well as therapeutic antibodies. This membrane protein is ideal for CNS neuroprotection in order to develop new treatments for insomnia, pain, depression, Alzheimer and Parkinson’s diseases. This class A GPCR is involved in the regulation of myocardial blood flow/hypertension and has a N-terminal Step tag II and an 8X His tag followed by a TEV protease cleavage site. Adenosine receptor A2A is a powerful therapeutic target especially found in the treatment of such conditions as insomnia, pain, depression, and Parkinson’s disease.