[Genovac] ANTI-HUMAN GRANZYME K MONOCLONAL ANTIBODY

[Genovac] ANTI-HUMAN GRANZYME K MONOCLONAL ANTIBODY

Catalog Number: GM-0202

Clone: GM-24C3

Description: purified monoclonal mouse antibody Specificity: anti-human Granzyme K (GrK; granzyme-3; NK-tryptase-2) Isotype: IgG2b/kappa

Purification: Protein G

Storage: short term: 2°C – 8°C; long term: –20°C (avoid repeated freezing and thawing)

Buffer: phosphate buffered saline, pH 7.2

Immunogen: genetic immunization with cDNA encoding human Granzyme K

Selection: based on recognition of the complete native protein expressed on transfected mammalian cells

Flow cytometry: 1.2 µg/106 cells ELISA: 1:200 – 1:400

CELISA: 1:200 – 1:400

For each application a titration should be performed to determine the optimal concentration

 

Granzyme K (GrK) belongs to a family of trypsin-like serine proteases localised in the cytotoxic granules of activated T cells and NK cells. It encodes a 28 kDa serine protease whose gene is located on chromosome 5q11-12 close to the granzyme A-encoding gene. Like granzyme A, it has a trypsin-like specifity cleaving at the basic residues arginine and lysine. Granzyme K triggers rapid cell death independently of caspase activation with single-stranded DNA nicks and is primarily expressed in thymus, lung, spleen and peripheral blood leukocytes.

 

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