[Iris Biotech] Halo-DBCO
- Product code:RL-3670
- CAS No.:1808119-16-5
- Formula:C29H35ClN2O4
- Molecular weight:511,06 g/mol
DESCRIPTION
A clickable HaloTag ligand. HaloTag is a modified bacterial haloalkane dehalogenase that reacts with chloralkane-containing ligands to form a covalent HaloTag-ligand conjugate. The reaction between the chloralkane linker and HaloTag is fast and irreversible under physiological conditions and the system has been used extensively to measure protein-protein interactions in cells.
The DBCO moiety shows enhanced kinetics in Click reactions due to its increased strain energy of the cyclooctyne moiety = strain-promoted azide-alkyne cycloaddition. Furthermore, this reaction benefits of increased biocompatibility as there is no requirement for cytotoxic Cu(I) as catalyst.
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