[Ruixibio] Linifanib (ABT-869)

[Ruixibio] Linifanib (ABT-869)

 

R-C-445

 

 

Molecular Weight	N/A
CAS	796967-16-3
PDI by GPC	<1.5
Solubility	Organic solvents
Storage	-20℃, protected from light and moisture
Transportation	4-25℃ temperature for up to 2 weeks
Stability	1 year

 

Linifanib(ABT-869) is a novel,potent ATP-competitive VEGFR/PDGFR inhibitor for KDR(IC50:4 nM),CSF-1R (IC50:3 nM),Flt-1/3(IC50:3/4 nM)and PDGFRβ(IC50:66 nM).Linifanib may exhibit potent antiproliferative and apoptotic effects on tumor cells whose proliferation is dependent on mutant kinases,such as FMS-related tyrosine kinase receptor-3 (FLT3).