[Calixar] Ion Channels

[Calixar] Ion Channels

Target

Description

 

hKCC2

CALIXAR’s Solute carrier family 12 member 5 (hKCC2) facilitates reliable fragment-based drug design (FBDD), structure-based drug discovery (SBDD), and antibody discovery against this specific target.

 

 

Product highlights

 

High Purity: Our products are rigorously purified and quality-controlled to meet the highest standards.

 

Biological Activity: We provide biologically active ion channel proteins to support functional studies.

 

Technical Support: Our team of experts is committed to assisting you in every aspect of your ion channel research journey.

 

CALIXAR provides our clients with the highest quality membrane ion channel proteins isolated in solution. CALIXAR’s ion channels are full-length, wild-type, pure, functional, and compatible with High Throughput Screening, immunizations, and structural studies by cryo-EM or X-Ray crystallography.

Ion channel function

Present in the membranes of all living cells, ion channels are pore-forming proteins that ensure the flow of charged ions from one side of a membrane to the other.

Eurofins CALIXAR’s integral membrane proteins are produced in their native physiological oligomeric state and in a thermostable form. As their functional and structural integrities are preserved, the purified ion channels may be useful for biological assays and structural-based drug developments. CALIXAR’s fully native ion channels are intended for all researchers involved in life science: pharmaceutical & biotech companies as well as academic groups. Our Ion Channel Targets are most suited for these types of life science projects:

• Drug Discovery
• Antibody Discovery
• Vaccine Discovery
• Immunoassays

Ion channel medical indication

Currently, the second largest target for existing drugs after GPCRs are ion channels, which represent promising targets for the development of additional, novel therapeutic agents in the near future.

Eurofins CALIXAR’s technology, which provides fully native ion channels for successful drug discovery programs, will contribute to this expansion.

Ion channel applications

Full-length and wild-type ion channel proteins developed by Eurofins CALIXAR are valuable for multiple applications such as small and large molecule screening, antibody development by immunization, and structural biology studies.

Ion channels are often large membrane proteins that may assemble in multimeric forms. The instability of the proteins or complexes can limit biological and structural developments.

Thanks to our patented molecules, Eurofins CALIXAR’s ion channels are thermostable and functional.